心肌梗死后缝隙连接和缓慢传导以及室性心动

SaffitzJE,KléberAG.GapJunctions,SlowConduction,andVentricularTachycardiaAfterMyocardial[J].JournaloftheAmericanCollegeofCardiology,,60(12):-.

Abstract：

EDITORIALCOMMENT

1.theyhaveallconvergedontheideathatgapjunctionremodelingcanreduceintercellularcouplingandtherebyslowconductioninwaysthatcontributeimportantlytothepathogenesisofre-entrantVTaftermyocardialinfarction.

2.Recognitionofthisconcepthasalsoraisedtheobviouspossibilitythatpreservationorenhancementofintercellularcouplinginthe

infarctborderzonemightdecreasetheriskforre-entrantVT.

3.concludethatincreasedexpressionofCx43inhealedinfarctborderzonesissuf?cienttoreducearrhythmiasusceptibilityandtheysuggestfurtherthattargetedCx43genetransfermightbeaviablefuturetherapyinpatientswithpost-infarctionVT.

4.Precisegeneticinterventionsinalargeanimalmodelwouldbeofgreatpotentialvalue,therefore,inelucidatingtheroleofspeci?cmoleculesinVTaftermyocardialinfarction

5.Potentialclinicalapplicationsofso-calledantiarrhythmicpeptidesorother







































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